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KMID : 0892920130220040337
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Experimental Neurobiology
2013 Volume.22 No. 4 p.337 ~ p.340
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Anti-LGI1 Limbic Encephalitis Presented with Atypical Manifestations
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Lee Jung-Ju
Lee Soon-Tae
Jung Keun-Hwa
Chu Kon
Lee Sang-Kun
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Abstract
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Anti-leucine-rich glioma inactivated-1 (LGI1) limbic encephalitis (LE) is a rare neurological disorder that has a subacute course of progressive encephalopathy and fasciobrachial dystonic seizures. We report a patient with anti-LGI1 LE that presented with atypical manifestations that complicated the diagnosis. A 62-year-old woman presented with a chronic course of memory disturbance and a subsequent relapse with an altered mental status after 10 months. The patient reported frequent chest pain of squeezing and dull nature, typically lasting 10-30 seconds. The chest pain was related to partial seizures, which were confirmed by video-EEG monitoring. Anti-LGI1 antibody was identified in serum and CSF. The patient's symptoms improved by immune modulation treatment. Patients with anti-LGI1 LE can experience atypical partial seizures, and a chronic relapsing course. Clinical suspicions and video-EEG monitoring are helpful for the early diagnosis and effective immune modulation.
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KEYWORD
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limbic encephalitis, chest pain, seizure, immune
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